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l + p a i n % 2 c + a n d + p a i n + i n + % 0 a + + + + + + e x t r e m i t y + t h e + s e r i o u s + a d v e r s e + r e a c t i o n s + w e r e + p u l m o n a r y + e m b o l i s m + a n d + % 0 a + + + + + + b l u r r e d + v i s i o n + w h i c h + w e r e + j u d g e d + t o + b e + t r e a t m e n t - r e l a t e d + n o + d e a t h s + o r + % 0 a + + + + + + u n e x p e c t e d + s e r i o u s + a d v e r s e + e v e n t s + r e l a t e d + t o + s t u d y + p r o d u c t + o c c u r r e d % 0 a + + + + % 0 a + + + + % 0 a + + + + + + a b o u t + g a m m a g a r d + l i q u i d % 0 a + + + + % 0 a + + + + % 0 a + + + + + + g a m m a g a r d + l i q u i d + i s + i n d i c a t e d + a s + r e p l a c e m e n t + t h e r a p y + f o r + p r i m a r y + h u m o r a l + % 0 a + + + + + + i m m u n o d e f i c i e n c y + % 2 8 p i % 2 9 + i n + a d u l t + a n d + p e d i a t r i c + p a t i e n t s + t w o + y e a r s + o f + a g e + % 0 a + + + + + + o r + o l d e r + t h i s + i n c l u d e s % 2 c + b u t + i s + n o t + l i m i t e d + t o % 2 c + c o m m o n + v a r i a b l e + % 0 a + + + + + + i m m u n o d e f i c i e n c y + % 2 8 c v i d % 2 9 % 2 c + x - l i n k e d + a g a m m a g l o b u l i n e m i a % 2 c + c o n g e n i t a l + % 0 a + + + + + + a g a m m a g l o b u l i n e m i a % 2 c + w i s k o t t - a l d r i c h + s y n d r o m e % 2 c + a n d + s e v e r e + c o m b i n e d + % 0 a + + + + + + i m m u n o d e f i c i e n c i e s % 0 a + + + + % 0 a + + + + % 0 a + + + + + + g a m m a g a r d + l i q u i d + i s + i n d i c a t e d + a s + a + m a i n t e n a n c e + t h e r a p y + t o + i m p r o v e + m u s c l e + % 0 a + + + + + + s t r e n g t h + a n d + d i s a b i l i t y + i n + a d u l t + p a t i e n t s + w i t h + m u l t i f o c a l + m o t o r + % 0 a + + + + + + n e u r o p a t h y + % 2 8 m m n % 2 9 % 0 a + + + + % 0 a + + + + % 0 a + + + + + + g a m m a g a r d + l i q u i d + w a s + o r i g i n a l l y + a p p r o v e d + b y + t h e + u s + f o o d + a n d + d r u g + % 0 a + + + + + + a d m i n i s t r a t i o n + % 2 8 f d a % 2 9 + i n + s e p t e m b e r + 2 0 0 5 + a l s o + k n o w n + a s + k i o v i g + o u t s i d e + t h e + % 0 a + + + + + + u n i t e d + s t a t e s + a n d + c a n a d a % 2 c + i t + i s + a p p r o v e d + i n + 5 1 + c o u n t r i e s + w o r l d w i d e % 0 a + + + + % 0 a + + + + % 0 a + + + + + + i m p o r t a n t + r i s k + i n f o r m a t i o n % 0 a + + + + % 0 a + + + + % 0 a + + + + + + + + r e n a l + d y s f u n c t i o n % 2 c + a c u t e + r e n a l + f a i l u r e % 2 c + o s m o t i c + n e p h r o s i s % 2 c + a n d + % 0 a + + + + + + + + d e a t h + m a y + o c c u r + w i t h + i m m u n e + g l o b u l i n + i n t r a v e n o u s + % 2 8 i g i v % 2 9 + p r o d u c t s + i n + % 0 a + + + + + + + + p r e d i s p o s e d + p a t i e n t s + p a t i e n t s + p r e d i s p o s e d + t o + r e n a l + d y s f u n c t i o n + % 0 a + + + + + + + + i n c l u d e + t h o s e + w i t h + a n y + d e g r e e + o f + p r e - e x i s t i n g + r e n a l + i n s u f f i c i e n c y % 2 c + % 0 a + + + + + + + + d i a b e t e s + m e l l i t u s % 2 c + a g e + g r e a t e r + t h a n + 6 5 % 2 c + v o l u m e + d e p l e t i o n % 2 c + s e p s i s % 2 c + % 0 a + + + + + + + + p a r a p r o t e i n e m i a % 2 c + o r + p a t i e n t s + r e c e i v i n g + k n o w n + n e p h r o t o x i c + d r u g s % 0 a + + + + + + % 0 a + + + + + + % 0 a + + + + + + + + r e n a l + d y s f u n c t i o n + a n d + a c u t e + r e n a l + f a i l u r e + o c c u r + m o r e + c o m m o n l y + i n + % 0 a + + + + + + + + p a t i e n t s + r e c e i v i n g + i g i v + p r o d u c t s + c o n t a i n i n g + s u c r o s e + g a m m a g a r d + l i q u i d + % 0 a + + + + + + + + d o e s + n o t + c o n t a i n + s u c r o s e % 0 a + + + + + + % 0 a + + + + + + % 0 a + + + + + + + + f o r + p a t i e n t s + a t + r i s k + o f + r e n a l + d 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m l % 2 f k g % 2 f h r % 2 9 % 2 c + a n d + % 0 a + + + + + + c o n s i d e r + d i s c o n t i n u a t i o n + o f + a d m i n i s t r a t i o n + i f + r e n a l + f u n c t i o n + % 0 a + + + + + + d e t e r i o r a t e s % 0 a + + + + % 0 a + + + + % 0 a + + + + + + g a m m a g a r d + l i q u i d + i s + c o n t r a i n d i c a t e d + i n + p a t i e n t s + w h o + h a v e + h a d + a + h i s t o r y + % 0 a + + + + + + o f + a n a p h y l a c t i c + o r + s e v e r e + s y s t e m i c + h y p e r s e n s i t i v i t y + r e a c t i o n s + t o + t h e + % 0 a + + + + + + a d m i n i s t r a t i o n + o f + h u m a n + i m m u n e + g l o b u l i n % 0 a + + + + % 0 a + + + + % 0 a + + + + + + g a m m a g a r d + l i q u i d + i s + c o n t r a i n d i c a t e d + i n + i g a - d e f i c i e n t + p a t i e n t s + w i t h + % 0 a + + + + + + a n t i b o d i e s + t o + i g a + a n d + a + h i s t o r y + o f + h y p e r s e n s i t i v i t y + a n a p h y l a x i s + h a s + % 0 a + + + + + + b e e n + r e p o r t e d + w i t h + t h e + i n t r a v e n o u s + u s e + o f + g a m m a g a r d + l i q u i d + a n d + i s + % 0 a + + + + + + t h e o r e t i c a l l y + p o s s i b l e + f o l l o w i n g + s u b c u t a n e o u s + a d m i n i s t r a t i o n % 0 a + + + + % 0 a + + + + % 0 a + + + + + + s e v e r e + h y p e r s e n s i t i v i t y + r e a c t i o n s + m a y + o c c u r % 2 c + e v e n + i n + p a t i e n t s + w h o + h a d + % 0 a + + + + + + t o l e r a t e d + p r e v i o u s + t r e a t m e n t + w i t h + h u m a n + n o r m a l + i m m u n e + g l o b u l i n + i n + c a s e + % 0 a + + + + + + o f + h y p e r s e n s i t i v i t y % 2 c + d i s c o n t i n u e + g a m m a g a r d + l i q u i d + i n f u s i o n + i m m e d i a t e l y + % 0 a + + + + + + a n d + i n s t i t u t e + a p p r o p r i a t e + t r e a t m e n t % 0 a + + + + % 0 a + + + + % 0 a + + + + + + h y p e r p r o t e i n e m i a % 2 c + i n c r e a s e d + s e r u m + v i s c o s i t y % 2 c + a n d + h y p o n a t r e m i a + m a y + o c c u r + % 0 a + + + + + + i n + p a t i e n t s + r e c e i v i n g + g a m m a g a r d + l i q u i d % 0 a + + + + % 0 a + + + + % 0 a + + + + + + t h r o m b o t i c + e v e n t s % 2 c + i n c l u d i n g + m y o c a r d i a l + i n f a r c t i o n % 2 c + c e r e b r a l + v a s c u l a r + % 0 a + + + + + + a c c i d e n t % 2 c + d e e p + v e i n + t h r o m b o s i s % 2 c + a n d + p u l m o n a r y + e m b o l i s m + h a v e + b e e n + % 0 a + + + + + + r e p o r t e d + i n + a s s o c i a t i o n + w i t h + i n t r a v e n o u s + u s e + o f + g a m m a g a r d + l i q u i d + % 0 a + + + + + + t h r o m b o t i c + e v e n t s + h a v e + a l s o + b e e n + r e p o r t e d + w i t h + s u b c u t a n e o u s + % 0 a + + + + + + a d m i n i s t r a t i o n + o f + i m m u n e + g l o b u l i n + p a t i e n t s + a t + r i s k + f o r + t h r o m b o t i c + % 0 a + + + + + + e v e n t s + i n c l u d e + t h o s e + w i t h + a + h i s t o r y + o f + a t h e r o s c l e r o s i s % 2 c + m u l t i p l e + % 0 a + + + + + + c a r d i o v a s c u l a r + r i s k + f a c t o r s % 2 c + a d v a n c e d + a g e % 2 c + i m p a i r e d + c a r d i a c + o u t p u t % 2 c + % 0 a + + + + + + c o a g u l a t i o n + d i s o r d e r s % 2 c + p r o l o n g e d + p e r i o d s + o f + i m m o b i l i z a t i o n % 2 c + o b e s i t y % 2 c + % 0 a + + + + + + d i a b e t e s + m e l l i t u s % 2 c + a c q u i r e d + o r + i n h e r i t e d + t h r o m b o p h i l i c + d i s o r d e r % 2 c + a + % 0 a + + + + + + h i s t o r y + o f + v a s c u l a r + d i s e a s e % 2 c + o r + a + h i s t o r y + o f + a + p r e v i o u s + t h r o m b o t i c + o r + % 0 a + + + + + + t h r o m b o e m b o l i c + e v e n t % 0 a + + + + % 0 a + + + + % 0 a + + + + + + a s e p t i c + m e n i n g i t i s + s y n d r o m e + m a y + o c c u r + w i t h + i g i v + t r e a t m e n t % 2 c + a n d + h a s + b e e n + % 0 a + + + + + + r e p o r t e d + w i t h + i n t r a v e n o u s + u s e + o f + g a m m a g a r d + l i q u i d + d i s c o n t i n u a t i o n + o f + % 0 a + + + + + + i g i v + t r e a t m e n t + h a s + r e s u l t e d + i n + r e m i s s i o n + o f + a m s + w i t h i n + s e v e r a l + d a y s + % 0 a + + + + + + w i t h o u t + s e q u e l a e + t h e + s y n d r o m e + u s u a l l y + b e g i n s + w i t h i n + s e v e r a l + h o u r s + t o + % 0 a + + + + + + t w o + d a y s + f o l l o w i n g + i g i v + t r e a t m e n t % 0 a + + + + % 0 a + + + + % 0 a + + + + + + g a m m a g a r d + l i q u i d + c o n t a i n s + b l o o d + g r o u p + a n t i b o d i e s + t h a t + m a y + a c t + a s + % 0 a + + + + + + h e m o l y s i n s + a n d + i n d u c e + i n + v i v o + c o a t i n g + o f + r e d + b l o o d + c e l l s + % 2 8 r b c % 2 9 + w i t h + % 0 a + + + + + + i m m u n e + g l o b u l i n + d e l a y e d + h e m o l y t i c + a n e m i a + c a n + d e v e l o p + s u b s e q u e n t + t o + % 0 a + + + + + + g a m m a g a r d + l i q u i d + t h e r a p y + d u e + t o + e n h a n c e d + r b c + s e q u e s t r a t i o n % 3 b + a c u t e + % 0 a + + + + + + h e m o l y s i s % 2 c + c o n s i s t e n t + w i t h + i n t r a v a s c u l a r + h e m o l y s i s % 2 c + h a s + b e e n + r e p o r t e d + % 0 a + + + + + + t h e + f o l l o w i n g + r i s k + f a c t o r s + m a y + b e + r e l a t e d + t o + t h e + d e v e l o p m e n t + o f + % 0 a + + + + + + h e m o l y s i s % 3 a + h i g h + d o s e s + % 2 8 e g % 2 c + % c 3 % a 2 % c 2 % 8 9 % c 2 % a 5 2 + g r a m s % 2 f k g % 2 c + s i n g l e + a d m i n i s t r a t i o n + o r + % 0 a + + + + + + d i v i d e d + o v e r + s e v e r a l + d a y s % 2 9 + a n d + n o n - o + b l o o d + g r o u p + u n d e r l y i n g + % 0 a + + + + + + i n f l a m m a t o r y + s t a t e + i n + a n + i n d i v i d u a l + p a t i e n t + m a y + i n c r e a s e + t h e + r i s k + o f + % 0 a + + + + + + h e m o l y s i s + b u t + i t s + r o l e + i s + u n c e r t a i n + m o n i t o r + p a t i e n t s + f o r + c l i n i c a l + s i g n s + % 0 a + + + + + + a n d + s y m p t o m s + o f + h e m o l y s i s % 2 c + p a r t i c u l a r l y + p a t i e n t s + w i t h + r i s k + f a c t o r s + n o t e d + % 0 a + + + + + + a b o v e % 0 a + + + + % 0 a + + + + % 0 a + + + + + + n o n - c a r d i o g e n i c + p u l m o n a r y + e d e m a + % 2 8 t r a l i % 2 9 + h a s + b e e n + r e p o r t e d + i n + p a t i e n t s + % 0 a + + + + + + f o l l o w i n g + t r e a t m e n t + w i t h + i g i v + p r o d u c t s % 2 c + i n c l u d i n g + g a m m a g a r d + l i q u i d + % 0 a + + + + + + m o n i t o r + p a t i e n t s + f o r + p u l m o n a r y + a d v e r s e + r e a c t i o n s % 0 a + + + + % 0 a + + + + % 0 a + + + + + + g a m m a g a r d + l i q u i d + i s + m a d e + f r o m + h u m a n + p l a s m a + i t + m a 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