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#AUA15 - Medical comorbidities, not neoadjuvant chemotherapy, affects decline ... - UroToday PDF Print
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NEW ORLEANS, LA USA (UroToday.com) - Despite level I evidence showing an improved overall survival in patients undergoing neoadjuvant chemotherapy (NAC), only about 20% of muscle-invasive bladder cancer (MIBC) patients undergo NAC in the United States. Patients who were eligible for NAC can become ineligible for cisplatin-based adjuvant chemotherapy (AC) if the renal function declines to GFR < 50 after radical cystectomy (RC). The group from Fox Chase Cancer Center sought to determine patient demographic and comorbidity history, including the use of NAC, impacting the decline of renal function to a threshold where platinum-based AC is no longer feasible.

auaThree hundred fifteen patients underwent RC between 2006 and 2011 and were identified from the institutional registry. Patients were included if their GFR was > 50 preop and they had a pathological diagnosis of primary urothelial MIBC. Adjusting for patient variables (age, gender, race), comorbidities (preop anticoagulation, CAD, afib/MI/PE, HTN, DM, DVT), receipt of NAC, intraoperative factors (EBL) and postoperative factors (Length of stay), logistic regressions were used to examine the determinants of eGFR < 50 measured anytime within 3 months postoperatively.

One hundred eighty-seven patients met criteria. Fifty-seven underwent NAC, and 130 patients did not. Of patients without NAC, 39 patients experienced a decline in eGFR < 50 (30%). On univariate analysis, presence of DM (OR 2.41, 95% CI 1.07-5.46) and presence of HTN (OR 2.37, 95% CI 1.24-4.53) were the only factors associated with increased risk of GFR decline < 50. In a multivariable model, only HTN (OR 2.26, 95% CI 1.05-4.84) was associated with increased risk. Receipt of NAC was not associated with GFR decline in either adjusted or unadjusted models.

The group concludes that up to 30% of patients with normal GFR preoperatively may become ineligible for platinum-based systemic therapy after RC based on renal function decline alone. Patients with medical comorbidities such as HTN and DM are particularly sensitive to this decline and should be encouraged to undergo NAC.

Presented and reported by Mohammed Haseebuddin, MD at the American Urological Association (AUA) Annual Meeting - May 15 - 19, 2015 - New Orleans, LA USA

Fox Chase Cancer Center, Philadelphia, PA USA

 

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The Insider, Javier Rodriguez Unloaded 36466 Shares of DaVita HealthCare ... - OctaFinance.com PDF Print

The Insider, Javier Rodriguez Unloaded 36466 Shares of DaVita HealthCare ... - OctaFinance.com

Javier Rodriguez Insider Sell Transaction

A few days ago, the CEO – Kidney Care of DaVita HealthCare Partners Inc (NYSE:DVA) 83.70 +0.50 0.60%, Mr. Javier Rodriguez, unloaded a significant amount company shares – 36,466, amounting to $2,972,001 U.S Dollars, based on an average weighted cost of $81.5 per share. It seems he is very active lately as in the last month, he unloaded additional 20,946 shares of the company, worth $1,771,403 USD. This transaction was pretty big one, so clearly it won’t go unnoticed. At the moment, Javier Rodriguez has rights to a total of 100,730 shares or 0.05% of the company’s market cap.

Davita Healthcare Partners Inc Stock Rating, Sentiment and Fundamentals

This move by Javier has led us to believe that the Company is expensive, with chances of the stock price going down. If Davita Healthcare Partners Inc posts $3.77 per share as forecasted by fifteen expert security analysts, Davita Healthcare Partners Inc will have 22.07 forward PE. Their expectations put the year-over-year earnings-per-share growth rate at 12.50%.

* Read How Our Stock Ratings System Works

Despite Javier Rodriguez’s trade, we have no choice but to rate the stock NEUTRAL as our trend following model as illustrated on the chart below, is flashing Buy. Davita Healthcare Partners Inc has seen its stock price increasing by up to 16.56% in the last 200 days, and currently the stock is in a reliable up trend.

Price Chart of Davita Healthcare Partners NYSE:DVA Stock

The Insider, Javier Rodriguez Unloaded 36466 Shares of DaVita HealthCare ... - OctaFinance.com

Source: RightEdgeSystems, Yahoo Split & Dividend Adjusted Data and OctaFinance Interpretations

The dated 19-05-2015 transaction’s document submitted with the (SEC) is freely accessible here.

Hedge Funds Ownership

According to SEC 13F filings for Q4 2014, 468 investment managers own shares of Davita Healthcare Partners Inc. In the last quarter, Davita Healthcare Partners Inc had 197.62% institutional ownership. That is a very high interest. Its up 140.93% from previous quarter. These institutional investors increased the total shares they own by 248.54 million to 424.89 million this quarter. A total of 30 funds closed their positions in Davita Healthcare Partners Inc and 158 reduced their holdings. There were 50 funds that created new positions and 189 funds that added to their positions.

16 hedge funds are positive about the stock and have it in their Top 10. Some of them are: Foundation Asset Management Lp, Swift Run Capital Management Llc, Summit Partners L P, Timessquare Capital Management Llc, Cognios Capital Llc, Triple Frond Partners Llc, Hikari Power Ltd, Gates Capital Management Inc., Hikari Tsushin Inc., Roundview Capital Llc.

HEDGE-FUNDS-LIST-DATABASE-FREE Bluestein R H & Co is the most positive hedge fund on Davita Healthcare Partners Inc, with ownership of 10,650 shares as of Q4 2014 for 0.05% of the fund’s portfolio. Dock Street Asset Management Inc is another positive institutional manager having 57,383 shares of the company or 2.29% of their stocks portfolio. The stock is also 1.06% of the fund’s AUM. First Republic Investment Management Inc. have 0.01% of their stock portfolio invested in the company for 7,274 shares. Further, The Massachusetts-based fund Foster Dykema Cabot & Co Inc Ma disclosed it had acquired a stake worth 2.05% of the fund’s stock portfolio in the company. The Illinois-based fund Geneva Advisors Llc was also a big follower of the stock, possessing 5,435 shares. Davita Healthcare Partners Inc is 0.01% of the fund’s stock portfolio.

DaVita HealthCare Partners NYSE:DVA Company Profile

DaVita HealthCare Partners Inc. offers kidney care and manages and operates medical groups. DaVita HealthCare Partners Inc. operates through DaVita Kidney Care and HealthCare Partners (HCP). The Company’s services include outpatient hemodialysis services, hospital inpatient hemodialysis services, Home-based hemodialysis services, ESRD laboratory services and management services. It operates or provides administrative services through a network of outpatient dialysis centers in the United States that are designed for outpatient hemodialysis. The Company provides hospital inpatient hemodialysis services, excluding physician services, to patients in hospitals throughout the United States. DaVita Kidney Care is a provider of kidney care in the United States, delivering dialysis services to patients with chronic kidney failure and end stage renal disease. HCP manages and operates medical groups and affiliated physician networks in Arizona, California, Nevada, New Mexico, and Florida.

Davita Healthcare Partners Inc was formed in Delaware on 1994-04-04. This company has 57900 employees. As of writing its market cap is: $17.89 billion and it has 216.32 million outstanding shares. Today it has 86.57% shareholders and the institutional ownership is 86.57%. The stock closed at $83.2 yesterday and it had average 2 days volume of 287000 shares. It is up from the 30 days average shares volume of 247747. Davita Healthcare Partners Inc has a 52weeks low of $67.27 and a one year high of $85.17. The stock price is above the 200 days Simple moving average. Davita Healthcare Partners Inc last issued its quarterly earnings report on 05/04/2015. The company reported 0.86 EPS for the quarter, above the consensus estimate of 0.85 by 0.01. The company had a revenue of 3.29 billion for 3/31/2015 and 3.33 billion for 12/31/2014. Therefore, the revenue was -40,052,000 down.

* Shares received upon the satisfaction of performance criteria underlying the awards of performance units.

* The sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 23 – 2015.

* Represents the weighted average sale price of $81.5006. The range of prices for the sale of these shares was $81.03 – $82.16 – rounded to the nearest hundredths. The reporting person undertakes to provide upon request by the Commission staff – the Issuer – or a security holder of the Issuer – full information regarding the number of shares purchased or sold at each separate price.

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Lehmkuhl increases pressure on ESRD Board to pave Ehmler Lane - The Elsberry Democrat PDF Print
Lehmkuhl increases pressure on ESRD Board to pave Ehmler Lane - The Elsberry Democrat

Ehmler Acres resident Larry Lehmkuhl addressed the E.S.R.D. Board on May 11 on behalf of himself and his neighbors and asked that Ehmler Lane finally be paved. That request, however, met with no small amount of resistance.

May 11 marked another chapter in the debate over whether or not to chip seal Ehmler Lane, a stretch of road running through the center of Ehmler Acres.

Residents of Ehmler Acres, a neighborhood located off of Hwy. W to the southwest of Elsberry, were represented at the May 11 meeting of the Elsberry Special Road District [E.S.R.D.] by Larry Lehmkuhl.

Lehmkuhl came to the meeting armed with written requests from every resident of Ehmler Acres urging the E.S.R.D. commissioners to finally approve the paving of Ehmler Lane.

Lehmkuhl stated that with oil prices being down the timing couldn’t be better with regard to meeting this request.

“It seems like this would probably be the best time for this to happen,” said Lehmkuhl.

Lehmkuhl added that to put one inch to one and a half inches of gravel on a road one mile long takes 968 tons of rock.

With gravel currently going for $4.50 per ton, the total cost for one application of rock on that same one-mile stretch is $4,356.

To gravel that same stretch twice per year would cost $8,712.

After presenting these figures, Lehmkuhl stated that a road such as Ehmler Lane that isn’t heavily traveled and gets only residential use would hold up with a chip seal surface for between six and eight years before requiring major work again.

He contrasted this with statistics in his possession indicating that the cost to gravel a road for seven years at $4.50 per ton would add up to $60,984.

Lehmkuhl argued that these numbers, combined with the fact that sales tax revenue has increased and new building starts throughout the county are up, make the application of a chip seal surface more affordable now than it has been in some time.

E.S.R.D. Presiding Commissioner Larry Wheeler replied that while he had no personal issues with the idea of paving Ehmler Lane, he wasn’t sure it was the responsible thing to do at this time from a financial standpoint.

Wheeler said the E.S.R.D. has an obligation to first give attention to those roads that are already chip sealed but received no upkeep last year.

He also pointed out that the district has a number of bridges and box culverts that need repair.

These arguments did not discourage Lehmkuhl, however.

“We would like to be moved up to the top of the list since we’ve been trying to get this done for eight years,” said Lehmkuhl.

Commissioner Jackie Briscoe asked Lehmkuhl whether he and the other residents of Ehmler Acres were prepared to chip in some of the costs that would be involved.

Lehmkuhl responded by saying that this was absolutely not an option.

Commissioner Joel Conderman then stated that paving Ehmler Lane would, in his opinion, be like opening Pandora’s Box.

He explained that several months ago when the notion of paving Ehmler Lane was reported in the newspaper, his phone had exploded with calls from angry residents who have been asking for their roads to be paved as well.

Conderman added that the uproar he had been forced to deal with went well beyond the controversy that erupted last year when the board decided to repave portions of Hatfield Road and Old Hwy. 79.

He further stated that the rule currently on the books states that the district is responsible for the maintenance and repair of the roads within its purview in their current form only and that decisions made with regard to paving roads need to be made in line with this policy.

Wheeler agreed and attempted to explain the necessity of such a policy to Lehmkuhl.

That’s where communication broke down, however.

“There is sure a lot of preferential treatment given to certain people living within the Elsberry Special Road District,” said Lehmkuhl. “If you’ve got the right last name you can get all kinds of things done.”

Wheeler denied that this was the manner in which decisions were made and the board subsequently took no action with regard to Lehmkuhl’s request.

In a follow-up interview, Lehmkuhl described the board as reactive rather than proactive and said the decision as to which roads to focus on this year should have been made in March rather than late May or early June.

“They don’t look forward,” said Lehmkuhl. “This is a good time to move forward, be progressive and do something positive for the road district. They could be taking advantage of the relatively low oil prices right now.”

Lehmkuhl said the board’s goal should be to get all of the roads paved and he has no sympathy for their limited funds after the amount of money that he feels was wasted last year on Old Hwy. 79 and Hatfield Road.

Lehmkuhl said that despite the fact that the board has kept him and the other residents of Ehmler Acres running in circles for the last eight years he plans to keep pursuing the issue for as long as it takes.

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Fire plays a role in landscape management - Peace River Record Gazette PDF Print

A prescribed fire was successfully burned along the valley 20 kilometres north of Peace River recently.

About 700 hectares of grass, debris and shrubs were ignited along the slopes.

Environment and Sustainable Resource Development and the Alberta Conservation Association have been working together to complete a number of prescribed fires along many of the river valleys in the Peace area.

“We’ve been working together since the ‘80s,” said Crystal Burrows, information officer, ESRD. “They came to us looking for help improving habitat along the valley; they help us identify the sites to burn.

“We’re basically in charge of operations – the planning of the prescribed fire and the implementation of the actual burn.

“We’ve also done over 50 hectares of hazards reduction burns around our own facilities – our camps, our lookouts (towers) and our fuel caches.

“Also the Town of Peace River and some (other) communities as well, including Cadotte, Martin River, Simon Lakes and Little Buffalo.”

These burns were done from mid-April to the first week of May.

Burrows pointed out the difference between prescribed fires and hazard reduction burns.

“Hazard reduction burns are the burning of dried, cured grasses. They are done by hand with a drip torch.

“Prescribed fires can be done with drip torches but (usually) helicopters do aerial ignition – dropping ignited fuel on forest vegetation - because they’re larger in scale.

“Prescribed fires,” Burrows continued, “can be done for a number of reasons, anything from mountain pine beetle control to ‘Fire Smarting’ (creating an area of less flammable vegetation), to improving habitat.

Fireguards are established before burns begin to ensure the fires are contained within the pre-determined boundaries. Fire suppression resources are strategically located to make sure the fire is contained. Measures are taken to limit the effects of smoke in the area and to have a minimal impact on nearby communities and residences.

Burrows said river valleys are important winter habitat. Early succession forest vegetation is especially important because the resulting shrub growth is important forage for the moose, deer and elk in such areas.

“By burning off the leaf and grass debris, the nutrients are returned to the soil and competition to forage plants is decreased, therefore increasing the food that is available for these animals. Fire in these stands also serves to decrease the tick populations, providing…another positive outcome for wildlife in the area.

“By imitating natural wildlife in a controlled manner, these projects will support the long term sustainability of these habitat areas.”

Burrows noted the prescribed fires provide “a plethora of information for the many scientists who study fire behaviour, while allowing ESRD the opportunity to provide hands-on training to their staff in a well-planned, controlled and non-emergency situation”.

The fire danger rating is high in the area. “In general, it’s been high all spring,” Burrows said. “We’ve had a very dry spring this year, with a lot of days with strong wind, which further helps dry out vegetation and of course, spreads fire faster.”

 

 

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NxStage Announces First Annual Zenith Award Winner - CNNMoney PDF Print

LAWRENCE, Mass., May 20, 2015 /PRNewswire/ -- NxStage Medical, Inc. (Nasdaq: NXTM) yesterday announced the Company's first annual Zenith Award winners, the critical care nurses in the Cardiovascular Intensive Care Unit (CVICU) at Medical City Dallas Hospital (MCDH). As a leading manufacturer of dialysis products, NxStage created the Zenith Award to recognize critical care nurses who deliver outstanding renal care to patients. NxStage is proud to recognize this group for their ability to improve timeliness of renal therapy for these patients, improve accuracy, and increase staff competency.

NxStage Medical, Inc.

The critical care team at MCDH achieved these results by involving physicians in catheter placement to reduce potential renal replacement treatment delays, collaborating with other ICU managers to extend training programs and reduce potential errors, and organized multiple hands-on learning opportunities to increase staff competency with the NxStage System One. Megan Brunson, RN Manager of MCDH's CVICU, submitted a nomination for the award on behalf of her team who proudly accepted it at a NxStage-sponsored educational event during the NTI & Critical Care Exposition in San Diego on May 19, 2015.

"The CVICU bedside staff articulated the need for excellence in the care of the renal patient and championed a multi-disciplinary approach," said Brunson. "As the flagship hospital of the North Texas Division of HCA, Medical City CVICU is honored to accept this award and continue to collaborate with NxStage on the improvement of care in this population of patients."

"NxStage is proud to recognize the accomplishments of critical care nurses for their dedication to patients," said NxStage President, Joe Turk. "NxStage recognizes how stressful the ICU environment is for critical care nurses and so we make it our mission to help simplify the delivery of renal replacement therapy through our technology.  We applaud the CVICU at Medical City Dallas, and all of the applicants, for their achievements."

About NxStage Medical
NxStage Medical Inc. (Nasdaq: NXTM) is a medical device company, headquartered in Lawrence, Massachusetts, USA, that develops, manufactures and markets innovative products for the treatment of ESRD and acute kidney failure. For more information on NxStage and its products, please visit the Company's website at www.nxstage.com.

Forward-Looking Statements
This release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this release that are not clearly historical in nature are forward-looking, and the words "anticipate," "believe," "expect," "estimate," "plan," and similar expressions are generally intended to identify forward-looking statements. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors including those that are discussed in NxStage's filings with the Securities and Exchange Commission, including the Quarterly Report on Form 10-Q for the quarter ended March 31, 2015. NxStage is under no obligation to (and expressly disclaims any such obligation to) update or alter its forward-looking statements, whether as a result of new information, future events or otherwise.

Media contact: 
Kristen K. Sheppard, Esq.
This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Tel: (978) 332-5923

Logo - http://photos.prnewswire.com/prnh/20110503/MM94799LOGO

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/nxstage-announces-first-annual-zenith-award-winner-300086477.html

SOURCE NxStage Medical, Inc.

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