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Stories from the dialysis comunity across the globe.
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FHN study finds frequent dialysis associated with higher vascular access risks. |
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Health Day News (JASN): In the first hospital-based trial, 31 percent of the 245 patients had to undergo repair of the blood-access site, lost use of the site or were hospitalized due to problems with the site. Complication rates were higher among the frequent-dialysis group: There were 33 repairs and 15 losses in the frequent-dialysis group compared with 17 repairs, 11 losses and one hospitalization in the standard-dialysis group. Overall, the risk for a problem with the blood-access site was 76 percent higher in the frequent-dialysis group than in the standard-dialysis group, the researchers reported.
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Randomized trial shows that switching from HD to online-HDF lowers mortality by 30%. |
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EurekAlert: Compared with patients who continued on hemodialysis, those assigned to OL-HDF had a 30% lower risk of dying from any cause, a 33% lower risk of dying from cardiovascular-related causes, and a 55% lower risk of dying from an infection.
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Cure for Chagas disease found? |
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EurekAlert: In The Journal of Infectious Diseases (JID), Galina Lepesheva, Ph.D., and her colleagues at Vanderbilt University and Meharry Medical College report curing both the acute and chronic forms of the infection in mice with a small molecule, VNI. VNI specifically inhibits a T. cruzi enzyme essential for cell multiplication and integrity. In mouse models of Chagas disease, VNI achieved cures with 100 percent survival and without toxic side effects.
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Are mycotoxin progenitor molecules found in grains responsible for kidney toxicity? |
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EurekAlert: Dall'Asta explains that these "masked mycotoxins" are not included in current safety regulations because of uncertainty about what happens when people and animals eat them. The new study focused on two of the most widespread mycotoxin contaminants of grain crops — deoxynivalenol (DON) and zearalenone (ZEN). The authors say their results show, for the first time, that bacteria present in the large intestine in people deconjugate or "unmask" DON and ZEN, releasing the original toxic forms. "For this reason, masked mycotoxins should be considered when evaluating population exposure," the study concludes.
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Another study shows increased cardiovascular risk in women with high calcium intake. |
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EurekAlert: Women who had a higher dietary intake of calcium exceeding 1400mg/day and also used supplements had a higher death rate compared to those not taking supplements. Women with a high dietary calcium intake (>1400 mg/day) were more than twice as likely to die compared with women with a 600-999mg/day calcium intake.
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