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Renal Cell Carcinoma Histologies - OncLive PDF Print

Renal Cell Carcinoma Histologies
The genetics and histologies among renal cell carcinoma (RCC) subtypes are heterogeneous, each representing a unique treatment challenge, states Eric Jonasch, MD. The clear cell histology is generally characterized as an angiogenic tumor with Von ...


Recombinant elastase (vonapanitase) for AV fistula patency prolongation PDF Print
Proteon Therapeutics Inc. (Nasdaq: PRTO), a company developing novel, first-in-class therapeutics to address the medical needs of patients with kidney and vascular diseases, today announced that the first patient has been treated in a second Phase 3 clinical study of investigational vonapanitase (formerly PRT-201), the company's lead product candidate. Here is a link to a previous article on this compound: http://www.jvascsurg.org/article/S0741-5214(14)00266-3/pdf


Music Aids Patient Recovery from Surgery - Renal and Urology News PDF Print
August 17, 2015 Music Aids Patient Recovery from Surgery - Renal and Urology News
Patients who listened to music had less pain, anxiety, and analgesia use after their operations, compared with patients receiving routine care or non-drug interventions.

Music can soothe the soul and the body. A new systematic review and meta-analysis confirms that listening to music improves patient recovery after surgical procedures.

Catherine Meads, PhD, of Brunei University in Uxbridge, UK, and colleagues analyzed 73 randomized controlled trials in which patients heard music before, during, or after surgery (with or without sedation or anesthesia). Unlike previous reviews, the researchers considered more than one aspect of the patient experience and all types of elective surgery from minor procedures to transplantation (with the exception of operations of the head, neck, or central nervous system). They also investigated the timing of music, choice of music, and the pairing of music and anesthesia. In the individual studies, music was compared to routine care, no music, white noise, or undisturbed bed rest.

The meta-analysis revealed that music decreased post-operative pain, anxiety, and use of pain medications, while increasing patient satisfaction, according to results published in The Lancet. It did not, however, affect length of hospital stay. The choice and timing of music made little difference, although most often it was soothing. Music even helped patients under general anesthesia (although the effects were larger when patients were awake).

“Modern theories of pain suggest that pain experience is affected by physical and psychological factors. Cognitive activities such as listening to music can affect perceived intensity and unpleasantness of pain, enabling patients' sensation of pain to be reduced,” the investigators explained. “Another potential mechanism could be reduced autonomic nervous system activity, such as reduced pulse and respiration rate and decreased blood pressure.”

Care needs to be taken to ensure music does not disturb the team performing the operation, the researchers stated. In most of the studies, the music volume was low enough that patients could hear instructions and respond to questions. It was delivered via headphones or music pillows directly to the patient or by a speaker that all could hear.

The investigators believe that enough evidence supports music that it should be made available to surgery patients with the conditions adapted to the clinical setting.  

  1. Hole, J; Hirsch, M; Ball, E; and Meads, C. The Lancet; doi: 10.1016/S0140-6736(15)60169-6.


Company Shares of NxStage Medical, Inc. (NASDAQ:NXTM) Rally 1.56% - American Trade Journal PDF Print

Shares of NxStage Medical, Inc. (NASDAQ:NXTM) rose by 1.56% in the past week and 28.57% for the last 4 weeks. In the past week, the shares have outperformed the S&P 500 by 0.88% and the outperformance increases to 30.73% for the last 4 weeks.

The company shares have rallied 37.93% in the past 52 Weeks. On April 27, 2015 The shares registered one year high of $19.63 and one year low was seen on September 16, 2014 at $11.5. The 50-day moving average is $14.92 and the 200 day moving average is recorded at $16.69. S&P 500 has rallied 6.56% during the last 52-weeks. The company has received recommendation from many analysts. 5 analysts have rated the company as a strong buy. The shares have been rated as hold from 1 Wall Street Analysts. 1 analysts have suggested buy for the company.1 analyst has also rated it as a strong sell. Nxstage Medical, Inc. is up 9.27% in the last 3-month period. Year-to-Date the stock performance stands at 1.9%. NxStage Medical, Inc. (NASDAQ:NXTM) : On Friday heightened volatility was witnessed in NxStage Medical, Inc. (NASDAQ:NXTM) which led to swings in the share price. The shares opened for trading at $18.14 and hit $18.4099 on the upside , eventually ending the session at $18.27, with a gain of 0.27% or 0.05 points. The heightened volatility saw the trading volume jump to 335,709 shares. The 52-week high of the share price is $19.63 and the company has a market cap of $1,159 million. The 52-week low of the share price is at $11.5 . Currently the company Insiders own 2.3% of Nxstage Medical, Inc. Company shares. In the past six months, there is a change of -6.42% in the total insider ownership. Institutional Investors own 94.4% of Company shares. During last 3 month period, -1.93% of total institutional ownership has changed in the company shares. On a different note, The Company has disclosed insider buying and selling activities to the Securities Exchange, According to the information disclosed by the Securities and Exchange Commission in a Form 4 filing, the (President) of Nxstage Medical, Inc., Turk Joseph E Jr had sold 3,252 shares worth of $57,690 in a transaction dated August 12, 2015. In this transaction, 3,252 shares were sold at $17.74 per share. NxStage Medical, Inc. (NxStage) is a medical device company that develops, manufactures and markets products for the treatment of kidney failure, fluid overload and related blood treatments and procedures. The Companys primary product is the NxStage System One (System One). It also sells needles and blood tubing sets primarily to dialysis clinics for the treatment of end-stage renal disease (ESRD). It operates in two segments: System One and In-Center. It distributes its products in three markets: home, critical care and in-center. In the System One segment it derives its revenues from the sale and rental of the System One and PureFlow SL equipment, and the sale of disposable products in the home and critical care markets. In the In-Center segment, it derives its revenues from the sale of blood tubing sets and needles for hemodialysis primarily for the treatment of ESRD patients at dialysis centers and needles for apheresis, which is referred to as the in-center market.


Serum Chloride Levels Linked to Mortality in Heart Failure Patients - Renal and Urology News PDF Print
August 17, 2015 Serum Chloride Levels Linked to Mortality in Heart Failure Patients - Renal and Urology News
Independent and inverse correlation seen for mortality with acute decompensated heart failure.

(HealthDay News) -- Serum chloride levels at admission are associated with mortality among patients with acute decompensated heart failure (ADHF), according to a study published in the Journal of the American College of Cardiology.

Justin L. Grodin, M.D., from the Cleveland Clinic, and colleagues examined the prognostic significant of sodium chloride levels in relation to serum sodium levels in a cohort of 1,318 patients with chronic heart failure admitted for ADHF. Findings were validated in an independent cohort of 876 ADHF patients.

The researchers observed an independent and inverse association for admission serum chloride levels during hospitalization for ADHF and long-term mortality (hazard ratio [HR] per unit change, 0.94; P < 0.001). After multivariable risk adjustment, admission chloride levels, but not sodium levels, remained independently associated with mortality (HR per unit change, 0.93; P < 0.001 and P > 0.05, respectively). Similar results were seen in the validation cohort in unadjusted and multivariable risk-adjusted analyses (HRs per unit change for mortality risk within one year, 0.93 [P < 0.001] and 0.95 [P = 0.01], respectively).

"These observations in a contemporary advanced ADHF cohort suggest that serum chloride levels at admission are independently and inversely associated with mortality," the authors write. "The prognostic value of serum sodium in ADHF was diminished compared with chloride."


  1. Grodin, JL; Simon, J; Hachamovitch, R; et al. J Am Coll Cardiol. 2015;66(6):659-666; doi:10.1016/j.jacc.2015.06.007.
  2. O'Connor, CM and Ahmad, T. J Am Coll Cardiol.2015;66(6):667-669; doi:10.1016/j.jacc.2015.05.070.


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