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Ketogenic diet reverses diabetic nephropathy in mice. |
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EurekAlert: When cells use ketones instead of glucose for fuel, glucose is not metabolized. Since high glucose metabolism causes kidney failure in diabetes, researchers hypothesized that the ketogenic diet would block those toxic effects of glucose. Considering the extreme requirements of the diet, it is not a long-term solution in adults. However, Dr. Mobbs' research indicates that exposure to the diet for as little as a month may be sufficient to "reset" the gene expression and pathological process leading to kidney failure. The researchers also identified a large array of genes expressed during diabetic nephropathy not previously known to play a role in the development of this complication. These genes are associated with kidney failure as a result of the stress on cellular function. The team found that the expression of these genes was also reversed in the mice on the ketogenic diet.
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