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Knockout model shows that kidney dopamine is an important modulator of blood pressure. |
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EurekAlert: They found that mice lacking kidney dopamine had high blood pressure at baseline and became more hypertensive when they consumed a high-salt diet, suggesting they may be a good model of salt-sensitive (essential) hypertension, Harris said. Alterations in the kidney dopamine system may predispose individuals to hypertension, he noted. The investigators also showed that elimination of kidney dopamine increased renin production, which activates the angiotensin II system to increase salt and water reabsorption – and produce hypertension. "These animals retain salt and water when they don't have sufficient dopamine production in the kidney," Harris said. "Our studies highlight this whole other hormonal system that appears to balance or put the brakes on the renin-angiotensin system."
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