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Stories from the dialysis comunity across the globe.
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Vascular type 1A angiotensin II receptors regulate renal blood flow and ... - Nature.com |
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Sepsis: Revising definitions of sepsis - Nature.com |
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Nature.com
The traditional definition of sepsis requires the presence of at least two systemic inflammatory response syndrome (SIRS) criteria in addition to a suspected or proven infection. A recent large retrospective study, however, suggests that the
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Lupus nephritis: MAINTAINing perspective in lupus nephritis trials - Nature.com |
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Nature.com
Despite aggressive therapy, lupus nephritis (LN) remains an important predictor of morbidity in patients with systemic lupus erythematosus. Clinical trials of novel drugs have not improved LN outcomes; however, re-analysis of well-characterized cohorts
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Comparison of amyloid deposition in human kidney biopsies as predictor of poor ... - 7thSpace Interactive (press release) |
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Comparison of amyloid deposition in human kidney biopsies as predictor of poor patient outcome
Amyloidosis leads to deposition of abnormal protein with beta-pleated sheet structure in specific compartments of the affected organs. The histological localization of these amyloid deposits determines the overall survival of the patient. Methods: In this study we have assessed the histological localization and severity of amyloid deposition in 35 patients with biopsy-proven renal amyloidosis and have compared those to clinical parameters, histo-pathological injury criteria and respective patient outcome. Comparisons were statistically analyzed using thus comparison between the different study groups, which was done using Student t-test and analysis of variance. Results: We find that the glomerulus is by far the most commonly and most severely affected renal compartment and patients with severe glomerular amyloidosis advance faster towards end stage renal disease (ESRD) and death, compared to those patients without glomerular amyloid deposits. Patients with severe glomerular amyloidosis showed higher serum creatinine and urine protein levels, while patients with severe vascular amyloidosis showed higher levels of interstitial inflammatory infiltrate. Conclusion: In kidneys affected by amyloidosis, the amyloid proteins are predominantly deposited along vessels, especially the small vessels including glomerular capillary loops. The severity of glomerular amyloid deposition enhances the risk of developing ESRD and increases the risk for premature death. Author: Ekaterina CastanoMatthew B PalmerChristine VigneaultRandy LucianoSerena WongGilbert Moeckel
Credits/Source: BMC Nephrology 2015, 16:64 Published on: 2015-04-28
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Dialysis: In-Hospital CPR Rates High, Survival Short After Discharge - Medscape |
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