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Stories from the dialysis comunity across the globe.



Health: New app dubbed 'Uber of healthcare' could aid dialysis patients - Yorkshire Evening Post PDF Print
Health: New app dubbed 'Uber of healthcare' could aid dialysis patients - Yorkshire Evening Post

Brendan Fatchett, director at 365 Response, with the new HealthCab app and software developer Luke Parkinson at Rota Master in Wakefield. Picture by Tony Johnson.

06:00 Monday 27 April 2015

Technology provides a quick, convenient fix to many daily dilemmas today, but could it soon be crucial to our health?

Ordering your food shop online or tracking your exercise with your smartphone is becoming the norm, prompting one Wakefield firm to attempt to make the humble mobile phone even more essential to some people’s lives.

Health: New app dubbed 'Uber of healthcare' could aid dialysis patients - Yorkshire Evening Post Brendan Fatchett, director of 365 Response, with the new HealthCab app and software developer Luke Parkinson at Rota Master, Wakefield. Picture by Tony Johnson.

Following a grant of almost £500,000 from the Department of Health’s Small Business Research Initiative, private consultancy firm 365 Response is building software dubbed the healthcare equivalent of taxi app Uber.

The HealthCab app would give seriously ill renal patients, who are in need of regular appointments for kidney dialysis treatment, the chance to book NHS-funded transport to and from hospital through their smartphone, check the credentials of their taxi, ambulance or volunteer driver and track the vehicle’s movements by GPS.

Brendan Fatchett, director of 365 Response, said it also aims to create a new standard for NHS commissioners to regulate patient transport and the suitability of the vehicles and drivers being used.

“We think this is a very vulnerable group of patients and they should have knowledge and understand who’s picking them up,” he said. “It’s about making it easier for patients to access the journeys, take away incredibly long waits and take out the ‘do not attends’ and aborted journeys. It’s giving renal patients confidence that they can live their lives in a normal way, while not having to squeeze down their dialysis.”

Set to be trialled with a small number of renal patients who have ‘twilight’ dialysis sessions at night in Leeds in the coming months, Mr Fatchett believes the app could better regulate and organise patient transport.

After two failed kidney transplants Janice Richardson, from Horsforth, needs three crucial dialysis sessions a week at Seacroft Hospital to remove waste from her blood.

The 52-year-old voiced fears that cuts were impacting renal patients earlier this year, having seen her transport become increasingly unreliable.

While stating that she had seen the service improve since the turn of the year, she said: “Sometimes it’s just totally normal taxis turning up and they wouldn’t know how to deal with health emergencies – bringing in more regulation would really help people particularly at twilight hours.

“There are quite a lot of patients that have had to reduce dialysis times. Instead of four hours they’re doing three or three and a half and as soon as you’re doing that you’re putting your life at risk.”

Although HealthCab is yet to be brought in, it seems the idea of controlling fundamental aspects of your own healthcare through your smartphone isn’t all that far away.

DIALYSIS IS KEY TO THE LIVES OF PATIENTS

Dialysis is a form of treatment that replicates many of the kidney’s functions.

The process filters blood to rid your body of harmful waste, extra salt and water.

It’s often used to treat advanced chronic kidney disease (kidney failure), where the kidneys have lost most or all of their ability to function.

More than 40,000 people in the UK are affected by kidney failure, with more than half of those receiving dialysis.

Most people who need to have dialysis are over 65 years of age.

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I kid(ney) you not: Renal Dialysis Unit, OPD inaugurated in Mansehra - The Express Tribune PDF Print
Governor Sardar Mehtab Ahmad Khan. PHOTO: SAMEER RAZZAQ/EXPRESS

Governor Sardar Mehtab Ahmad Khan. PHOTO: SAMEER RAZZAQ/EXPRESS

PESHAWAR: 

The Renal Dialysis Unit and outpatient department services of Pakistan Kidney Centre in Mansehra were officially inaugurated on Sunday.

According to a handout, the facility was inaugurated by Governor Sardar Mehtab Ahmad Khan. The centre is working under the umbrella of the Pakistan Welfare Society Trust’s Abbottabad chapter.

Mehtab lauded the role of non-government organisations and institutions in the fight against various diseases, especially kidney-related ailments. He asked the wealthier segment of society to contribute and encourage such bodies which are working towards the elimination of disease. “The government has limited resources and it cannot cater to the needs of people on its own,” said the governor. Therefore, he added, it was crucial to involve the private sector.

The governor said thousands were affected by kidney diseases in Khyber-Pakhtunkhwa due to lack of education and awareness. He said nobody could deny the importance of kidneys which expel unnecessary and harmful chemical waste.

“The country has been gripped by the war on terror for the last 10 years and it is a common phenomenon that doctors and other educated individuals started moving abroad.” Some of these people were saving part of their earnings and sending money back to their home country, he added. The governor revealed some of these funds were being utilised on welfare projects and the kidney centre was a prime example.

Published in The Express Tribune, April27th, 2015. 

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Panic grips Odisha village after 20 youths die of renal disease - Odisha Sun Times PDF Print

Odisha Sun Times Bureau
Anandpur, April 26:

With more than 20 young people – most of them below 25 years of age – dying within a year’s span due to renal diseases, panic has gripped a cluster of tribal dominated villages on either side of the National Highway in Odisha’s mineral rich Keonjhar district.

mystery disease

Besides the 20 dead, several others in Gohira, Uparsahi, Badasahi, Patharkundisahi, Mahisabahali, Kalabila and Sunatangiri located not very far from the block headquarters are battling for their lives after being afflicted with the disease.

While villagers are succumbing one after another to the disease, the Health department has limited its activities to merely conducting a survey with no efforts to contain it. Astoundingly, the Health department is yet to find out the cause behind the spread of the disease and the resultant deaths though it has been prevalent for more than a year now.

In the last one year, eight have died of the disease in Uparsahi, seven in Badasahi, five in Patharkundisahi and three in Sunatangiri.  Kamal Kumar Nayak, Biranchi Nayak and Kanaklata Nayak of the last named village have died of the disease in the last one month. More than 20 are currently bedridden after being afflicted with the disease. With the death of the earning members, the families are living in penury and are broke.

Most of the deaths have occurred after prolonged suffering. While villagers earlier believed the spread of the disease was due to high iron content in the drinking water in the area, now suspect it to be a case of wtchcraft.

Left with no option, tribals have requisitioned the services of witch doctors to ascertain the cause behind the spread of the disease and its arrest. A priest from Champua and local dehurys have begun pooja from Saturday evening at the village. Villagers participating in the pooja said that the reason behind the disease and the deaths will be ascertained very soon. Around five thousand villagers have participated in the pooja leaving their work.

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Renal failure: location signals for cell division - HealthCanal.com PDF Print

Researchers identify molecules that help cells to pinpoint their position

For the kidneys to function flawlessly, millions of cells must be arranged precisely according to a specified blueprint. Scientists at the Max Planck Institute for Heart and Lung Research in Bad Nauheim and Philipps-Üniversität Marburg have now discovered that kidney cells send signals to neighbouring cells undergoing division to organize the repairing of the kidneys after acute renal failure. The findings may help in future to improve the regeneration of damaged organs.

The kidneys continuously filter waste and toxic substances from the blood, which are then removed from the body via the urine. Filtration occurs in numerous microscopic tubes, known as tubules, the inner surface of which is covered by epithelial cells. Similar to boat planking, the individual epithelial cells in the tubules must be precisely arranged for the kidneys to function normally.

Intensive-care patients often suffer kidney failure, during which some of the epithelial cells die. The resulting gaps are closed by surviving epithelial cells from the surrounding area, which divide to form new cells. However, it is crucial for the new cells to be positioned at precisely the right location. If this is not the case, dividing cells could block the bore of the tubules and impair the function of the kidneys.

The spatial arrangement of the dividing epithelial cells is determined by the orientation of the spindle apparatus, a bundle of protein threads that pull the chromosomes towards the opposite poles of the cell and distributes them equally between the new cells. The Research Group led by Thomas Worzfeld at the Max Planck Institute for Heart and Lung Research in Bad Nauheim and at the Pharmacological Institute in Marburg have now investigated how the orientation of the spindle apparatus is controlled during cell division.

To this effect, the scientists from Bad Nauheim and Marburg discovered that neighbouring epithelial cells communicate with each other with the help of signal molecules. In this way they influence the orientation of the spindle apparatus and control the spatial arrangement of the new cells. “As in a GPS system, there are antennas that receive signals. This function is assumed by the plexin B2 receptor, which receives a location signal from neighbouring cells,” explains Worzfeld.

The location signal itself consists of a group of signal molecules called semaphorins. Through genetic manipulation, Worzfeld’s Group switches off individual semaphorins in mice. As a result, the epithelial cells no longer arrange themselves correctly and block the tubules. “We observed the same phenomenon in mice lacking the plexin B2 receptor, meaning the antenna,” says Worzfeld.

In both cases, the damaged kidney was unable to regenerate, and it remained functionally impaired. “In this study we discovered a previously unknown function of the plexin B2 receptor and its binding partners, the semaphorins,” explains Worzfeld. It involves a fundamental mechanism by which the kidneys heal following renal failure. The scientists now want to investigate whether plexin B2 and the semaphorins also play a role in the repair of other organisms and in diseases such as cancer.

  Max-Planck-Gesellschaft, München

MH/HR

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Correlation of renal histopathology with renal echogenicity in dogs and cats ... - 7thSpace Interactive (press release) PDF Print
  Correlation of renal histopathology with renal echogenicity in dogs and cats: an ex-vivo quantitative study Increased cortical or cortical and medullary echogenicity is one of the most common signs of chronic or acute kidney disease in dogs and cats. Subjective evaluation of the echogenicity is reported to be unreliable. Patient and technical-related factors affect in-vivo quantitative evaluation of the echogenicity of parenchymal organs. The aim of the present study is to investigate the relationship between histopathology and ex-vivo renal cortical echogenicity in dogs and cats devoid of any patient and technical-related biases. Results: Kidney samples were collected from 68 dog and 32 cat cadavers donated by the owners to the Veterinary Teaching Hospital of the University of Padua and standardized ultrasonographic images of each sample were collected. The echogenicity of the renal cortex was quantitatively assessed by means of mean gray value (MGV), and then histopathological analysis was performed. Statistical analysis to evaluate the influence of histological lesions on MGV was performed. The differentiation efficiency of MGV to detect pathological changes in the kidneys was calculated for dogs and cats. Statistical analysis revealed that only glomerulosclerosis was an independent determinant of echogenicity in dogs whereas interstitial nephritis, interstitial necrosis and fibrosis were independent determinants of echogenicity in cats. The global influence of histological lesions on renal echogenicity was higher in cats (23%) than in dogs (12%). Conclusions: Different histopathological lesions influence the echogenicity of the kidneys in dogs and cats. Moreover, MGV is a poor test for distinguishing between normal and pathological kidneys in the dog with a sensitivity of 58.3% and specificity of 59.8%. Instead, it seems to perform globally better in the cat, resulting in a fair test, with a sensitivity of 80.6% and a specificity of 56%. Author: Alessandro ZottiTommaso BanzatoMaria GelainCinzia CentellegheCalogero VaccaroLuca Aresu
Credits/Source: BMC Veterinary Research 2015, 11:99 Published on: 2015-04-24
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